Parameters for selecting biological features in multifunctional bio-inspired design: a convergent evolution approach.

Combining different biological features exhibiting different functions is necessary to generate uncommon and unique multifunctional bio-inspired conceptual designs. Different biological features independently evolve characteristics to solve the same need/necessity. This phenomenon is called convergent evolution. Without parameters, selecting a suitable feature from those that exhibit the same function and have the same geometric relevance becomes quite difficult. This research investigates and identifies the parameters that have the potential to support choosing the suitable biological feature and to support the multifunctional design concept generation. In this paper, parameters are hypothesized by studying the mechanisms of tissue formation responsible for generating structural features in a biological system. These parameters are used in the Expandable Domain Integrated Design (xDID) ideation model to aid designers in choosing and combining suitable biological features for multifunctional concepts. A case study is presented to validate the effectiveness of the parameters in the selection process .

RACares: a conceptual design to guide mHealth relational agent development based on a systematic review.

Background: A relational agent (RA) is a digital tool tailored to communicate with users, aiming to establish a sense of social ease and emotional bond, particularly focusing on their health and well-being concerns. A mobile health (mHealth) RA is particularly crafted to communicate with users within their mobile devices. As healthcare becomes increasingly digital, these mHealth RAs can serve as personal health assistants, e.g., guiding users through medical regimens, offering reminders for medication, providing emotional support during health crises, or even aiding in mental well-being exercises. Their accessibility, especially for those in remote areas, can bridge the gap between patients and immediate health assistance, revolutionizing the way healthcare is approached and delivered. Methods: In this paper, our primary focus is introducing a conceptual design for mHealth RAs with the aim of enhanced user engagement, personalized health interventions, consistent support, data collection and monitoring, and enhanced multimodal accessibility. To develop this conceptual design, we employed an inductive approach. This involved conducting a qualitative analysis on data gathered from a systematic literature review of RAs. Consequently, this analysis allowed us to identify a taxonomy of key design features essential for RAs. Results: This paper provides a conceptual design of mHealth RAs which includes five stages: user input receiving stage, input processing stage, data analysis stage, output processing stage, and output generation stage. A stage is a logical assembly of interconnected functionalities (components) that work together to accomplish a certain objective or set of goals. Each stage's outputs are used as inputs in the stages that follow after it. There is also a Data and Personalization Controller for aiding the data analysis stage. The stages are logically arranged one after another as follows: input, process, analysis, and output. Conclusions: The conceptual design aims to create RAs for various mHealth applications, including patient education, mental health counseling, and chronic disease management. This design is crucial in digital health research as it enhances patient-RA interactions, potentially improving health outcomes and experiences in non-life-threatening scenarios where RAs can be an alternative to human healthcare professionals (HCPs).

Aerial Continuum Manipulation: A New Platform for Compliant Aerial Manipulation.

Traditional aerial manipulation systems were usually composed of rigid-link manipulators attached to an aerial platform, arising several rigidity-related issues such as difficulties of reach, compliant motion, adaptability to object's shape and pose uncertainties, and safety of human-manipulator interactions, especially in unstructured and confined environments. To address these issues, partially compliant manipulators, composed of rigid links and compliant/flexible joints, were proposed; however, they still suffer from insufficient dexterity and maneuverability. In this article, a new set of compliant aerial manipulators is suggested. For this purpose, the concept of aerial continuum manipulation system (ACMS) is introduced, several conceptual configurations are proposed, and the functionalities of ACMSs for different applications are discussed. Then, the performances of proposed aerial manipulators are compared with conventional aerial manipulators by implementing available benchmarks in the literature. To enhance the comparison, new features with related benchmarks are presented and used for evaluation purposes. In this study, the advantages of ACMSs over their rigid-link counterparts are illustrated and the potential applications of ACMSs are suggested. The open problems such as those related to dynamic coupling and control of ACMSs are also highlighted.

Realization of user-friendly bioanalytical tools to quantify and monitor critical components in bio-industrial processes through conceptual design.

This minireview suggests a conceptual and user-oriented approach for the design of process monitoring systems in bioprocessing. Advancement of process analytical techniques for quantification of critical analytes can take advantage of basic conceptual process design to support reasoning, reconsidering and ranking solutions. Issues on analysis in complex bio-industrial media, sensitivity and selectivity are highlighted from users' perspectives. Meeting challenging analytical demands for understanding the critical interplay between the emerging bioprocesses, their biomolecular complexity and the needs for user-friendly analytical tools are discussed. By that, a thorough design approach is suggested based on a holistic design thinking in the quest for better analytical opportunities to solve established and emerging analytical needs.

Product Development of Natural Fibre-Composites for Various Applications: Design for Sustainability.

New product development review article aims to consolidate the principles and current literature on design for sustainability to seek the field's future direction. In this point of view, the design for sustainability methods can be established under the idea of sustainability in dimensions of ecology, economy and social pillars. Design for sustainability concept is implemented in concurrent engineering, including concept, embodiment and detail design processes. Integrating sustainability in engineering designs is crucial to producing greener products, system innovation, and services aligned with current market demand. Currently, many concurrent engineering studies related to natural fibre-reinforced polymer composites associated with sustainability enhance the application of design for sustainability techniques by professional designers. However, the current literature is scarce in bridging the design for sustainability concept with concurrent engineering during the design development stage, and these areas should be further developed. Several other future research directions, such as the need for aligning with principles and applications, along with exploring the relationships between the design for sustainability techniques and views of sustainability, are presented in this review paper.

Analysis of the routes for biomass processing towards sustainable development in the conceptual design step: Strategy based on the compendium of bioprocesses portfolio.

Process sustainability has been one of the most challenging issues faced by process designers. Conceptual designed processes do not overcome this stage because aspects such as context and technological readiness level are left aside. This paper proposes a strategy to consider different processing routes for biomass (compendium of existing routes) towards sustainable development. The strategy comprises five stages where a supported bioprocesses selection is made by considering the chemical composition of the raw material and the context where biomass is produced and processed. This strategy aims to give decision tools to designers to filter and reduce the number of options to be considered when proposing an alternative biomass use. The proposed strategy was applied to upgrade orange peel waste and sugarcane bagasse to demonstrate how it can be applied. In conclusion, selecting of bioprocesses and considering the proposed strategycould improve the biorefineries design. Even so, more bioprocesses must be included.

CDFA method: a way to assess assembly and installation performance of aircraft system architectures at the conceptual design.

This paper describes an engineering design methodology, called conceptual design for assembly (CDFA) in the context of aircraft development, to assess aircraft systems' installation during conceptual phase, in relation to industrial performance objectives. The methodology is based on a given framework (hierarchical structure) which includes a set of attributes, collected in recognized domains that characterize the aircraft systems installation. The framework of the CDFA methodology enables to analyze product architectures at different levels of granularity, splitting the global analysis into sub-problems (problem discretization) with the aim to help architects and designers to identify product architecture weaknesses in terms of fit for assembly performances. The CDFA methodology was applied on a complex system (the nose-fuselage of a commercial aircraft) presenting a high number of criticalities both for the product and its assembly operations. Results identified the architectural components leading to the less efficient assembly operations and the rationales enabling to elaborate alternative architectures for an improved product industrial efficiency.

Main Problems Using DEM Modeling to Evaluate the Loose Soil Collection by Conceptual Machine as a Background for Future Extraterrestrial Regolith Harvesting DEM Models.

Nowadays, rapid product development is a key factor influencing a company's success. In the Space 4.0. era, an integrated approach with the use of 3D printing and DEM modeling can be particularly effective in the development of technologies related to space mining. Unfortunately, both 3D printing and DEM modeling are not without flaws. This article shows the possibilities and problems resulting from the use of DEM simulation and 3D printing simultaneously in the rapid development of a hypothetical mining machine. For the subsequent development of the regolith harvesting model, loose soil harvesting simulations were performed and the underlying problems were defined and discussed. The results show that it is possible to use both technologies simultaneously to be able to effectively and accurately model the behavior of this type of machine in various gravitational conditions in the future.

Conceptual Study and Manufacturing of a Configurable and Weld-Free Lattice Base for Automatic Food Machines.

The study is aimed at developing a modular lattice base for automatic food machines, starting with a solution already patented by some of the authors. In this case, welded carpentry modules were interlocked with a system of profiles and metal inserts, also in welded carpentry, and the union was stabilized by structural adhesive bonding. Since welding involves long processing times and thermal distortions to be restored later, the driver of this study is to limit the use of welding as much as possible while increasing the modularity of the construction. For this purpose, various solution concepts have been generated where a common feature is the presence of rods of the same geometry and section to be joined together in configurable structural nodes. The concepts are qualitatively evaluated in light of the requirements, and the selected concept is digitally and physically prototyped. The prototype has been in service from over 5 years without showing any problems whatsoever.

An inclusive study on new conceptual designs of passive solar desalting systems.

Potable water is one of the vital necessities for the society. The assurance of availability of clean water to society is a big confront due to restricted accessibility of clean water on planet Earth. Solar desalting systems can be used for justifying the appropriate supply of fresh water in distant localities by the use of ample sunlight. In spite of conventional solar desalting systems, various other designs of solar desalting systems are used to boost the overall performance of the system. In this work, various new conceptual designs of passive solar desalting systems have been reviewed to understand better, efficient and productive performing system along with various novel solar desalting systems that can inculcate the real feeling of performing information among the researchers. An overview has also been established for better utility indications and comparative performances among all solar desalting systems. The interpretations have been accomplished with the better results and some favor has also been recommended for the future betterment and building novel designs to meet the feasible hurdles.

Development and control of a home-based training device for hand rehabilitation with a spring and cable driven mechanism.

Rehabilitation at home is rapidly increasing. Although successful results are achieved with treatment methods applied in rehabilitation clinics, there are also some disadvantages in this process, such as dependence on an expert and high costs. Developments in mechatronic technologies have accelerated the development of assistive devices which are designed for use at home. One of the rehabilitation applications is on a hemiplegic hand. In previous studies, some useful devices have been developed for hand rehabilitation. In this study, we suggest a new, low-cost and wearable robotic glove for hand rehabilitation. The specific component of this device is the spring and cable driven system proposed for transmission of motion and force. The device was tested on both unimpaired participants and patients with the hemiplegic hand, and it was proven to be beneficial for hand rehabilitation. As a result of trials with unimpaired participants, the muscle activation of the extensor digitorum and the flexor carpi radialis were increased by 184.1 and 197.8% respectively. The weight of the device was less than 400 g, thanks to 3D printed parts.

A comprehensive approach for biorefineries design based on experimental data, conceptual and optimization methodologies: The orange peel waste case.

The aim of this work was to propose a comprehensive methodological approach integrating two of the most applied approaches to design biorefineries based on experimental data: conceptual design and optimization. The proposed methodology involves three critical aspects i) experimental procedures, ii) simulation approach, and iii) optimization tools. The proposed approach was applied to a specific case as an example. The orange peel waste (OPW) was studied as raw material to feed the biorefinery with the purpose of valorizing the residues produced by the orange juice factories in the Colombian context. After implementing the methodology, the results show how essential oil and biogas were the most profitable and reliable products to be obtained through the processing of OPW.In this case, it is demonstrated also, that the understanding of the biorefinery possibilities is higher when this design methodology is applied.

Design of a Pilot SOFC System for the Combined Production of Hydrogen and Electricity under Refueling Station Requirements.

The objective of the current work is to support the design of a pilot hydrogen and electricity producing plant that uses natural gas (or biomethane) as raw material, as a transition option towards a 100% renewable transportation system. The plant, with a solid oxide fuel cell (SOFC) as principal technology, is intended to be the main unit of an electric vehicle station. The refueling station has to work at different operation periods characterized by the hydrogen demand and the electricity needed for supply and self-consumption. The same set of heat exchangers has to satisfy the heating and cooling needs of the different operation periods. In order to optimize the operating variables of the pilot plant and to provide the best heat exchanger network, the applied methodology follows a systematic procedure for multi-objective, i.e. maximum plant efficiency and minimum number of heat exchanger matches, and multi-period optimization. The solving strategy combines process flow modeling in steady state, superstructure-based mathematical programming and the use of an evolutionary-based algorithm for optimization. The results show that the plant can reach a daily weighted efficiency exceeding 60%, up to 80% when considering heat utilization.

A Systematic Study on Design Initiation of Conceptual 3DPVS.

An important product in biomedical and biomimetic engineering is the 3D scaffold, which mimics the real tissue in vitro to achieve the external cultivation of cells. The difference between the 3D scaffold and other biomimetic products lies in the fact that the former mimics the internal features of tissue, while the latter generally approximates the external traits of biological beings. In the field of scaffold engineering, the 3D printed vibratory scaffold, 3DPVS, has been proposed as a present-to-future novel scaffold product, and it currently stays at the stage of conceptual development. To achieve the novel design of the conceptual 3DPVS, a conceptual design process has been established by authors in their previous work, which contain three main stages, namely the design initiation, concept generation, and concept evaluation. In terms of design initiation, it is a 'must-accomplish' stage which generates outputs for both the subsequent concept generation and evaluation. Work of design initiation therefore is of significant value and it consists of several tasks; that is, conducting a thorough literature review, summarizing the fundamental issues preparing the general conceptual design, studying the multi-characterization of the 3DPVS, putting forward the potential base model(s), as well as indicating the ideality of the scaffold and establishing potential ideal model(s) for the 3DPVS. In this paper, design initiation will be chiefly focused upon these essential aspects to be discussed, work of which is expected to be useful in establishing a solid ground for future innovation work of the 3DPVS.

Techno-economic evaluation and conceptual design of a liquid biofertilizer plant / Evaluación técnico-económica y diseño conceptual de una planta de biofertilizantes líquidos

ABSTRACT Biofertilizers have become an effective, eco-friendly and low cost alternative to chemical fertilizers. Process engineering and cost models for a biofertilizer plant with a production capacity of 44 tons of liquid biofertilizer per year (568 kg/batch) were developed. The models were obtained using process simulator (SuperPro Designer®), version 8.5 (Intelligen, 2012), while the 3D conceptual design and layout of the biofertilizer plant was developed with (OptiPlant®) software (ASD Global, 201 5). The total capital investment required to erect the plant is $ 3 975 000, the unit production cost of one 1.5 L bottle of liquid biofertilizer is $ 24.009, while the economic indicators Net Present Value (NPV) and Internal Rate of Return (IRR) had values of $ 716 000 and 2.55%, respectively. Also, the total revenues are $ 985 000/year, the Return on Investment (ROI) is 14.93 %, and the payback time is 6.70 years.

RESUMEN Los biofertilizantes se han convertido en una alternativa de bajo costo, efectiva y amigable con el medio ambiente en comparación con los fertilizantes químicos. En el presente trabajo se desarrollaron los modelos de ingeniería de proceso y costo de una planta de biofertilizantes líquidos con una capacidad de 44 toneladas por año (568 kg/lote). Los modelos fueron obtenidos empleando el simulador de procesos SuperPro Designer® versión 8.5 (Intelligen, 2012), mientras que el diseño conceptual en 3D y dimensionamiento de la planta se desarrolló mediante el software OptiPlant (ASD Global, 2015). Se requiere una inversión total de USD $ 3 975 000 para erigir la planta, el costo de producción unitario de una botella de 1,5 L de biofertilizantes líquido es de USD $ 24,009, mientras que los indicadores económicos Valor Actual Neto (VAN) y Tasa Interna de Retorno (TIR) tuvieron valores de USD $ 716 000 y 2,55 %, respectivamente. También se obtienen ganancias totales de USD $ 985 000/año y un valor del Período de Retorno de la Inversión de 6,70 años.

Recent Developments and Challenges in Optimization-Based Process Synthesis.

This article first reviews recent developments in process synthesis and discusses some of the major challenges in the theory and practice in this area. Next, the article reviews key concepts in optimization-based conceptual design, namely superstructure representations, multilevel models, optimization methods, and modeling environments. A brief review of the synthesis of major subsystems and flowsheets is presented. Finally, the article closes with a critical assessment and future research challenges for the process synthesis area.

Conceptual design of a high-speed electromagnetic switch for a modified flux-coupling-type SFCL and its application in renewable energy system.

The modified flux-coupling-type superconducting fault current (SFCL) is a high-efficient electrical auxiliary device, whose basic function is to suppress the short-circuit current by controlling the magnetic path through a high-speed switch. In this paper, the high-speed switch is based on electromagnetic repulsion mechanism, and its conceptual design is carried out to promote the application of the modified SFCL. Regarding that the switch which is consisting of a mobile copper disc, two fixed opening and closing coils, the computational method for the electromagnetic force is discussed, and also the dynamic mathematical model including circuit equation, magnetic field equation as well as mechanical motion equation is theoretically deduced. According to the mathematical modeling and calculation of characteristic parameters, a feasible design scheme is presented, and the high-speed switch's response time can be less than 0.5 ms. For that the modified SFCL is equipped with this high-speed switch, the SFCL's application in a 10 kV micro-grid system with multiple renewable energy sources are assessed in the MATLAB software. The simulations are well able to affirm the SFCL's performance behaviors.

A New XYZ Compliant Parallel Mechanism for Micro-/Nano-Manipulation: Design and Analysis.

Based on the constraint and position identification (CPI) approach for synthesizing XYZ compliant parallel mechanisms (CPMs) and configuration modifications, this paper proposes a new fully-symmetrical XYZ CPM with desired motion characteristics such as reduced cross-axis coupling, minimized lost motion, and relatively small parasitic motion. The good motion characteristics arise from not only its symmetric configuration, but also the rigid linkages between non-adjacent rigid stages. Comprehensive kinematic analysis is carried out based on a series of finite element simulations over a motion range per axis less than ±5% of the beam length, which reveals that the maximum cross-axis coupling rate is less than 0.86%, the maximum lost motion rate is less than 1.20%, the parasitic rotations of the motion stage (MS) are in the order of 10-5 rad, and the parasitic translations of the three actuated stages (ASs) are in the order of 10-4 of the beam length (less than 0.3% of the motion range), where the beam slenderness ratio is larger than 20. Furthermore, the nonlinear analytical models of the primary translations of the XYZ CPM, including the primary translations of the MS and the ASs, are derived and validated to provide a quick design synthesis. Moreover, two practical design schemes of the proposed XYZ CPM are discussed with consideration of the manufacturability. The practical designs enable the XYZ CPM to be employed in many applications such as micro-/nano-positioning, micro-/nano-manufacturing and micro-/nano-assembly. Finally, a spatial high-precision translational system is presented based on the practical design schemes, taking the actuator and sensor integration into account.

Center of Excellence to build nursing scholarship and improve health care in Italy.

PURPOSE: This article profiles the establishment and initial phase (2010-2014) of a Center of Excellence (CoE) as an instrument to strengthen nursing scholarship and improve health care in Italy. APPROACH: This CoE is unique as a non-university-based center. The National Regulatory Board of Registered Nurses, Health Visitors, and Pediatric Nurses (IPASVI) designated substantial administrative and funding support to the CoE for advancing nursing education, clinical practice, research development, and research training. Boyer's Model of Scholarship underpinned the CoE's conceptual framework, and its operational infrastructure was adapted from the U.S. National Institutes of Health P20 program award mechanism. Diverse methods included sponsoring research studies by nurse-led teams, research training courses, nursing education longitudinal studies, evidence-based practice training, and related pilot studies. FINDINGS: Multiple collaborative projects were conducted via the CoE in conjunction with the successful launch of an expansive digital library and communication system accessible to nurses. The introduction of English proficiency courses was also a unique contribution. CONCLUSIONS: The CoE concept is a potential instrument to strengthen nursing scholarship in Italy with potential scalability considerations to other global settings. CLINICAL RELEVANCE: An overlapping focus on research, education, and practice under the umbrella of nursing scholarship within a CoE while engaging all levels of nursing is important to impact healthcare changes.

Design considerations and quantitative assessment for the development of percutaneous mitral valve stent.

Percutaneous heart valve replacement is gaining popularity, as more positive reports of satisfactory early clinical experiences are published. However this technique is mostly used for the replacement of pulmonary and aortic valves and less often for the repair and replacement of atrioventricular valves mainly due to their anatomical complexity. While the challenges posed by the complexity of the mitral annulus anatomy cannot be mitigated, it is possible to design mitral stents that could offer good anchorage and support to the valve prosthesis. This paper describes four new Nitinol based mitral valve designs with specific features intended to address migration and paravalvular leaks associated with mitral valve designs. The paper also describes maximum possible crimpability assessment of these mitral stent designs using a crimpability index formulation based on the various stent design parameters. The actual crimpability of the designs was further evaluated using finite element analysis (FEA). Furthermore, fatigue modeling and analysis was also done on these designs. One of the models was then coated with polytetrafluoroethylene (PTFE) with leaflets sutured and put to: (i) leaflet functional tests to check for proper coaptation of the leaflet and regurgitation leakages on a phantom model and (ii) anchorage test where the stented valve was deployed in an explanted pig heart. Simulations results showed that all the stents designs could be crimped to 18F without mechanical failure. Leaflet functional test results showed that the valve leaflets in the fabricated stented valve coapted properly and the regurgitation leakage being within acceptable limits. Deployment of the stented valve in the explanted heart showed that it anchors well in the mitral annulus. Based on these promising results of the one design tested, the other stent models proposed here were also considered to be promising for percutaneous replacement of mitral valves for the treatment of mitral regurgitation, by virtue of their key features as well as effective crimping. These models will be fabricated and put to all the aforementioned tests before being taken for animal trials.